布拉德-皮特和安吉丽娜-朱莉所扮演的史密斯夫妇在外人眼里是一对令人羡慕的夫妻，但二人各自效力于一个秘密组织，而且彼此隐瞒了自己“职业杀手”的身份。直到一次相同的刺杀任务，夫妻俩暗斗的结果是两败俱伤。
在追查破坏自己行动元凶的过程中，夫妻俩逐渐开始怀疑对方。直到妻子在晚餐中无意将自己敏捷的身手暴露给同是内行的杀手丈夫后，夫妻俩共同居住了七年的双层别墅立时成为了杀人战场。
不过，多年的夫妻情谊，加之身手又在伯仲之间，史密斯夫妇最终选择放下武器。但所在组织并不愿意放过他们，为了逃避各自顾主所派出的杀手追杀，两位顶级杀手联合起来，开始疯狂的报复行动。
John and Jane Smith are a couple who have been married for 6 years and things appear to be normal. But it appears that things are changing--they are seeing a marriage counselor. And what neither of them know is that they are professional assassins. However, they are both assigned by their employers to kill the same person. When they each try to take out the target, they get in each other's way and blow the job. Now they are told to go after the person who made them miss the target. And when they learn about each other, they try to take each other out.
单词注释：
couple：夫妇
counselor：顾问
assassin：刺客，暗杀者
target：目标
，皮特和安吉丽娜联手上演史密斯夫妇